Invasive

Klebsiella pneumonia are gram-negative rod and intestinal parasite known >> << nosocomial infections and infections in infected hosts. In

in the last 15 years, however, a new type of invasive K. pneumonia

disease appeared in Taiwan, which is usually manifested as outpatient

primary liver abscess in patients without biliary tract or other intra-abdominal

infections. K. pneumonia

is a single pathogen can be identified. The syndrome of sepsis and bacteremia are common

with metastatic meningitis or septic endoftalmit complicates

, usually in 10-12% of cases. Diabetes, which can be a factor

can be found in approximately 50% of patients, while others were

no apparent underlying disease. Another presentation of invasive disease

K. pneumonia is community acquired meningitis. There

gradual increase in community acquired meningitis caused by

K. pneumonia in Taiwan since 1987. After 1996

K. pneumonia replace Streptococcus

pneumonia as the leading bacterial pathogen outpatient >> << meningitis in adults. Although responsible

K. pneumonia strains were equally exposed to all cephalosporins and aminoglycosides,

mortality reaches 10-20% for primary liver abscess and up

30ЎV40% of those with meningitis have been reported. Invasive

K. pneumonia disease in Taiwan a new threat to public health and

deserves further attention and study. Structural >> << Genomics is a new and rapidly evolving field of Life Sciences. Purpose

in this area is to identify and analyze structures and

depending on all proteins in nature in order to lay the groundwork for a fundamental understanding

biology. Several genome projects

been completed recently. The next step after genomic research

yield a complete genome sequence of the type is to identify the

as cellular and molecular functions of each gene in the genome. Several >> << pilot projects in structural genomics on the way. Previous

The results of these pilot projects shows additional data on the functional analysis of genome >>. << Both approaches are important for genomic research

by DNA sequencing. In this program the project, we propose to develop the

and include the methodology and technology for structural genomics and proteomics

Research

Klebsiella pneumonia and associated with >> < <proteins involved in cell cycle. This

Bioinformatics website for Klebsiella pneumonia structural genomics

(http://kp. Life strattera dosing. Nthu. Education. TW /). Using bioinformatics, high throughput

cloning, expression and purification of protein targets,

structural analysis of different biophysical methods and proteomics research

at the cellular functions

Klebsiella pneumonia, we

expect a decision on a new protein structure 10-20 per year. In addition to structural genomics research, the specific proteins for cellular

reactions induced Klebsiella pneumonia or

major virulence factors in a comparative study of differential protein expression profiling

as in sub-cellular organelles and whole cells

will be studied by proteomics approaches such as 2D gel mass

, spectroscopy, confocal microscopy, etc. Completion of this project >> << extend our understanding of atomic basis

Klebsiella pneumonia, provide a significant shortcut to understanding its function gene

and generate the most fundamental genomic data than

consistency of the information. Structural and functional information

eventually help in understanding the molecular mechanisms of cellular response to >>

<< Klebsiella pneumonia infection. In addition, results

from this project can give an insight to the prevention and treatment

related >> << Klebsiella pneumonia. . << >>